INHERITANCE OF STRESS-INDUCED ATF-2-DEPENDENT EPIGENETIC CHANGE PDF

When the stress is turned on, ATF-2 changes its function and induces Inheritance of Stress-Induced, ATFDependent Epigenetic Change. A typical example of epigenetics is DNA methylation, which is important for . ATF‐2 is a target of the stress‐activated protein kinase p Recently .. Inheritance of dATF‐2‐dependent, stress‐induced epigenome change. Alterations to epigenetic states allow the organism to adapt to Inheritance of stress-induced, ATFdependent epigenetic change. Cell

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Inheritance of stress-induced, ATFdependent epigenetic change. – FPrime

Atf1, the fission yeast homolog of activation transcription factor-2 ATF-2contributes to heterochromatin formation. However, the role of ATF-2 in chromatin assembly in higher organisms remains unknown. The dATF-2 protein colocalized with HP1, not only on heterochromatin but also at specific loci in euchromatin.

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Heat shock or osmotic stress induced phosphorylation of dATF-2 and resulted in its release from heterochromatin. This heterochromatic disruption was an epigenetic event that was transmitted to the next generation in a non-Mendelian fashion. When embryos were exposed to heat stress over multiple generations, the defective chromatin state was maintained over multiple successive generations, though it gradually returned to the normal state.

The results suggest a mechanism by which the effects of stress are inherited epigenetically via the regulation of a tight chromatin structure. This entry form currently does not support special characters. Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.

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Inheritance of stress-induced, ATF-2-dependent epigenetic change.

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