GAMAPATIA MONOCLONAL PDF

Summary. This term does not characterize a disease but a group of diseases. To learn about the diseases included under this term, you can consult the. Monoclonal gammopathy of undetermined significance (MGUS) is the most common of a spectrum of diseases called plasma cell dyscrasias. World J Nephrol. Mar 6;6(2) doi: /wjn.v6.i Monoclonal gammopathy of renal significance: Diagnostic workup. Correia SO(1), Santos.

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Immunoglobulin M monoclonal gammopathy of undetermined significance IgM-MGUS was diagnosed in Mayo Clinic patients who were residents of 11 counties in southeastern Minnesota from to Smoldering WM was identified in 48 patients at Mayo Clinic from to During follow-up, 33 of the 48 patients progressed monoclonwl symptomatic WM.

The median time to progression was 4. Monoclonal gammopathy of undetermined significance was diagnosed in Mayo Clinic patients from to who were residents of 11 counties in southeastern Minnesota.

The median age at diagnosis was 74 years range, 24—94 years. The gamapatis of the serum M protein at diagnosis ranged from unmeasurable to 2.

The serum albumin level ranged from 1.

The patients were followed for person-years median, 6. Progression occurred slowly in most patients, but some progressed more rapidly. Patients with IgM-MGUS had a shorter median survival time than expected for Minnesota residents of matched age and sex, 7 years versus The number of patients with progression to a lymphoid neoplasm or a related disorder 29 patients was Patients with a diagnosis of CLL or lymphoma or a history of any antineoplastic therapy were excluded.

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Monoclonal gammopathy of renal significance: Diagnostic workup.

The median age at diagnosis was 63 years range, 39—87 years. The initial hemoglobin level ranged from 8. The initial median leukocyte level was 5. The serum monoclonal protein level at the time of diagnosis ranged from 1.

The amount of the urine M protein ranged from unmeasurable to 1. Serum albumin ranged from 2. The 48 patients were followed for a total of person-years range, 0. The median survival after progression to symptomatic WM was 5. Seventy-three percent of the patients died, indicating a robust follow-up. We evaluated sex, hemoglobin level, amount of serum M protein, reduction of uninvolved immunoglobulins, presence of urinary monoclonal light chains, serum albumin level, and the proportion of lymphoplasmacytic infiltration of the bone marrow as risk factors for progression.

Monoclonal gammopathy of renal significance: Diagnostic workup.

Significant risk factors for progression with univariate analysis included amount of the serum M protein, hemoglobin level, reduction of uninvolved immunoglobulins, and degree of bone gamapatiaa lymphoplasmacytic cell infiltration.

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Multivariate modeling revealed that the amount of the M protein and the degree of bone marrow infiltration were the most important risk factors.

Neither mohoclonal these conditions should be treated. National Center for Biotechnology InformationU. Author manuscript; available in PMC Sep Author information Copyright and License information Disclaimer. The publisher’s final edited version of this article is gamapatix at Clin Lymphoma Myeloma. See other articles in PMC that cite jonoclonal published article. Abstract Immunoglobulin M monoclonal gammopathy of undetermined significance IgM-MGUS was diagnosed in Mayo Clinic patients who were residents of 11 counties in southeastern Minnesota from to Open in a separate window.

Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: Long-term follow-up of IgM monoclonal gammopathy of undetermined significance. Monoclonal gammopathy of undetermined significance, Waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: The spectrum of IgM monoclonal gammopathy in cases. A long-term study of prognosis in monoclonal gammopathy of undetermined significance [see comment] N Engl J Med.

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